Hépato-Gastro & Oncologie Digestive


Abnormalities in iron status Volume 20, issue 8, Octobre 2013

CHU Pontchaillou, Service des maladies du foie, 35033 Rennes, France

Hyperferritinemia may correspond to either tissular iron overload or not. Hepatic iron overolad syndromes are classified as (i) acquired when associated with hematologic, metabolic or hepatic disorders responsible for abnormal iron metabolism or (ii), rarely, genetic when related to either HFE and non HFE hemochromatosis (through impaired hepdicin production) or nonhemochromatotic conditions (through impaired iron recycling) such as ferroportin disease or aceruloplasminemia. Hyperferritinemia with no tissular iron overload corresponds also to (i) acquired conditions, namely metabolic syndome, cell necrosis, excessive alcohol consumption and inflammatory syndrome and (ii) genetic disorders by mutation on the L ferritin gene. Common clinical sense, simple biochemical tests, magnetic resonance imaging and genetic molecular tools allow for a precise and non invasive diagnosis of most cases of hyperferritinemia.