Malaria remains a leading cause of morbidity, particularly in sub-Saharan Africa. In the context of global warming, more knowledge is needed about the possible relations between changes in local climate parameters and occurrence of malaria. This study analyzes the changing climate parameters (rain, relative humidity, minimum, average and maximum temperatures) and their potential impact on the dynamics of malaria in the Marahoué region in west-central Côte d’Ivoire. Climate data from 1980 to 2013 and malaria cases recorded from 2009 to 2013 in various health facilities in the region were analyzed statistically. The results show an increase in malaria morbidity in the Marahoué region during the months of April to May and October to November, coinciding with the (more and less) rainy seasons. Furthermore, significant correlations were observed between rainfall (0.44 in Bouaflé; 0.36 in Zuénoula), maximum temperature (Sinfra -0.36; Zuénoula -0.31), relative humidity (Sinfra 0.38; Zuénoula 0.42) and malaria morbidity.