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The association between CCL2 polymorphisms and drug-resistant epilepsy in Chinese children Volume 15, issue 3, September 2013

Dong L, Luo R, Tong Y, et al. Lack of association between ABCB1 gene polymorphisms and pharmacoresistant epilepsy: an analysis in a western Chinese pediatric population. Brain Res 2011 ; 1391 : 114-124.

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Foresti ML, Arisi GM, Katki K, Montañez A, Sanchez RM, Shapiro L.A. Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. J Neuroinflammation 2009 ; 6 : 40.

Ghosh C, Gonzalez-Martinez J, Hossain M, et al. Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow. Epilepsia 2010 ; 51 : 1408-1417.

Lakhan R, Kumari R, Singh K, Kalita J, Misra UK, Mittal B. Possible role of CYP2C9 and CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy. Indian J Med Res 2011 ; 134 : 295-301.

Letendre S, Marquie-Beck J, Singh KK, et al. The monocyte chemotactic protein-1-2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid. J Neuroimmunol 2004 ; 157 : 193-196.

Lorigados Pedre L, Morales Chacón LM, Orozco Suárez S, et al. Inflammatory mediators in epilepsy. Curr Pharm Des 2013. In press.

Marchi N, Teng Q, Ghosh C, et al. Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity. Brain Res 2010 ; 1353 : 176-186.

Marchi N, Granata T, Freri E, et al. Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. PLoS One 2011 ; 6 : e18200.

Maroso M, Balosso S, Ravizza T, et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 2010 ; 16 : 413-419.

McDermott DH, Yang Q, Kathiresan S, et al. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation 2005 ; 112 : 1113-1120.

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Pham MH, Bonello GB, Castiblanco J, et al. The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance. PLoS One 2012 ; 7 : e49498.

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Siddiqui A, Kerb R, Weale ME, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 2003 ; 348 : 1442-1448.

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Stamatovic SM, Dimitrijevic OB, Keep RF, Andjelkovic A.V. Protein kinase C alpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. J Biol Chem 2006 ; 281 : 8379-8388.

Vezzani A, Balosso S, Maroso M, Zardoni D, Noé F, Ravizza T. ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy. Curr Opin Investig Drugs 2010 ; 11 : 43-50.

Walker L, Sills G.J. Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?. Epilepsy Curr 2012 ; 12 : 8-12.

Wu Y, Wang X, Mo X, et al. Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy. Clin Neuropathol 2008 ; 27 : 55-63.

Yao Y, Tsirka S.E. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. J Cell Sci 2011 ; 124 : 1486-1495.