John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Somatosensory evoked potentials and eeg findings in siblings of juvenile myoclonic epilepsy patients Volume 1, issue 3, Septembre 1999


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Bakirköy Ruh ve Sinir Hastaliklari Hastanesi, 1. Nöroloji Klinigi. 34740, Bakirköy/Istanbul- Turkey.
  • Key words: juvenile myoclonic epilepsy, siblings, somatosensory evoked potentials, and electroencephalography
  • Page(s) : 173-8
  • Published in: 2000

Purpose: In order to demonstrate cortical hyperexitability and to determine the efficacy of ‘SEP of high amplitude (HASEP) in detecting asymptomatic relatives of JME patients, we evaluated the EEG findings and SEP in asymptomatic siblings of JME patients. Methods: We analysed the EEG and SEP findings of 37 JME patients and 48 asymptomatic siblings of 27 patients and compared the results with healthy volunteers. Results: Of 13 asymptomatic siblings with EEG abnormalities (27.1%), 5 had 4-6 Hz spike/polyspike and wave paroxysms (10.4%), 5 had slow wave paroxysms (10.4%), and the remaining 3 patients exhibited focal spike and wave activity during hyperventilation (6.25%). No significant difference was found between JME patients, asymptomatic siblings and control groups with respect to N20 latencies. N20/P25 amplitudes were significantly higher in both JME group and asymptomatic siblings than those of control cases. HASEP were observed in 8 out of 37 JME patients (21.6%), 10 out of 48 healthy siblings (20.8%) and none of the control cases. The consanguinity rate was higher in parents of patients who had at least one asymptomatic sibling with EEG and/or SEP abnormalities (68.7%) than in those of patients who had siblings with no EEG and SEP abnormalities (9.9%). We suggest that the high rate of SEP and EEG changes among offspring of consanguineous marriages might reflect the genetic heterogeneity of the disease.