Figure 2
Clinical course. Seizures presenting as eyelid twitching were initially noticed at 1 year and 5 months of age. Seizures were refractory to carbamazepine (CBZ) and levetiracetam (LEV). At 2 years of age, seizure frequency increased when the dosage of valproate (VPA) was decreased, but at 4 years of age, the frequency did not change even when discontinued. At 2 years of age, frequent seizure episodes were reduced by ethosuximide (ESM). Seizures were aggravated after decreasing the ESM dosage at 3 years of age, but were alleviated by an increased dosage of lamotrigine (LTG) and ESM.