JLE

Epileptic Disorders

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Molecular genetics of the idiopathic epilepsies: the next steps... Volume 2, issue 4, Décembre 2000


   
  

Figure. Progress in the molecular genetics of epilepsy has occurred by molecular geneticists studying selected families that were carefully characterised by clinical researchers (arrow 1). This in turn has led to refinements in the understanding of the clinical spectrum of certain genetic epilepsies (arrow 2). Future research must evaluate these molecular genetic discoveries in populations defined by genetic epidemiological studies (arrow 3). Such populations, when carefully clinically characterised, may also provide clinical material for further molecular discoveries (arrow 4) and allow further refinements to the phenotypic spectrum, initially defined by studies on special families (arrow 5).