Epileptic Disorders
MENULGI-1 antibody encephalitis in a seven-year-old girl Volume 21, issue 6, December 2019
TEST YOURSELF
(1) LGI-1 limbic encephalitis can be seen in:
A. Adults
B. Children
C. Both adults and children
D. None of the above
(2) LGI-1 limbic encephalitis can present with which of the following seizure types?
A. Faciobrachial dystonic seizures
B. Focal seizures with automatisms
C. Generalized tonic-clonic seizures
D. All of the above
(3) What is the first-line treatment for LGI-1 limbic encephalitis presenting with very frequent seizures?
A. Antiepileptic drugs
B. Pharmacological coma
C. Combination of IVIG and steroids
D. IVIG
Answers
(1) C. LGI-1 limbic encephalitis can be seen in both adults and children. A high index of suspicion is also needed in children to appropriately diagnose and treat this condition.
(2) D. Patients with LGI-1 limbic encephalitis can present with multiple seizure types including characteristic FBDS, focal seizures with automatisms, generalized tonic-clonic seizures, drop attacks, and myoclonic seizures.
(3) C. Antiepileptic drugs alone usually are not helpful. First-line treatment includes glucocorticoids and IVIG, and combination of the two has been shown to be better. Patients show an excellent response to immunotherapy.