John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Lamotrigine triggers the contact phase of coagulation Volume 14, issue 2, June 2012

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Institute of Laboratory Medicine and Pathobiochemistry, University Hospital, Baldingerstr, D-35043 Marburg, Germany

epd.2012.0503 Auteur(s) : Thomas W Stief thstief@med.uni-marburg.de Institute of Laboratory Medicine and Pathobiochemistry, University Hospital, Baldingerstr, D-35043 Marburg, Germany To the editor, Lamotrigine has been described to be able to prolong activated partial thromboplastin time (aPTT) and produce skin eruption (Yeom et al., 2011). Lamotrigine is a trigger of the contact phase of coagulation, the intrinsic system of coagulation (Stief, 2012); plasma concentrations of about 2 mg/L [...]