Figure 2
Upper panel - temporal distribution of spikes during the whole night in a single representative subject with ESES. Notice the rather stable values of IEDs over the consecutive cycle. The hypnogram is shown under the IED profile. Lower panel - Model of normalized SWA and SFA time course in the first NREM sleep cycle in ESES. The distribution of IEDs per minute in a single subject shows a strong correlation with SFA and an inverse time course with respect to SWA, especially between the two dotted vertical lines where SFA and SWA have diverging behavior. ESES, Encephalopathy related to Status Epilepticus during slow Sleep; IEDs, interictal epileptiform discharges; SFA, spindle frequency activity; SWA, slow wave activity. Modified with permission from (Nobili et al., 2001).