Department of Functional and Stereotactic Neurosurgery and Gamma Knife Radiosurgery, Timone University Hospital, Marseille, France
Aix Marseille Université, Inserm, L’Institut de Neurosciences des Systèmes (INS, UMR1106), Marseille, France
Functional Neurosurgery and Stereotaxy Unit, Neurological Surgery Department, Tanta University, Egypt
Department of Neurosurgery, Timone University Hospital, Marseille, France
Department of Clinical Neurophysiology, Timone University Hospital, Marseille, France
University of Lyon, Université Claude Bernard Lyon, Lyon, France
Department of Neurosurgery, Hospices Civils de Lyon, Neurology and Neurosurgery, Member of the ERN EpiCARE, Hospital Pierre Wertheimer, Bron, France
Correspondence: Hussein Hamdi
Department of Functional and Stereotactic Neurosurgery and
Gamma Knife Radiosurgery,
Timone University Hospital, Marseille, France
Drop attacks are the most responsive seizure type to open callosotomy, however, surgical complications can worsen the prognosis. Various less invasive techniques have been explored in an effort to minimize the risk. We present a patient who suffered from life-threatening traumatizing drop attacks in whom previous open anterior callosotomy and vagal nerve stimulation were unsatisfactory. Following posterior extension of the callosotomy by non-invasive gamma knife surgery, the rate of drop attacks declined from 30 a day to once a day, or every few days over a four-month period, without complications.
Open callosotomy is an invasive and high risk treatment option for patients with drop attacks. The procedure has a potential for complications and neurological consequences that can worsen the functional capacity of a patient who already suffers with disability. Recently, in an attempt to decrease the invasiveness associated with this technique, additional technical refinements and less invasive procedures have been explored in a few studies.
Here, we report a case of refractory epilepsy with life-threatening traumatizing DA, in which the patient was treated by radiosurgical posterior callosotomy after unsatisfactory open anterior callosotomy and vagal nerve stimulation.