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Early experiences with tachycardia-triggered vagus nerve stimulation using the AspireSR stimulator Volume 18, issue 2, June 2016

TEST YOURSELF

(1) What does vagus nerve automatic magnet mode stimulation mean (AMM)?

 

(2) How was ictal tachycardia defined in the initial E-36 trial (Boon et al., 2015) and is this definition of IT required to implant an Aspire model?

 

(3) How does the neurologist need to titrate individually the seizure detection algorithm (SDA)?

 

 

 

 

 

 

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Answers

(1) The AspireSRTM VNS model was designed to detect ictal tachycardia (IT) using a patented cardiac-based seizure-detecting algorithm (SDA). The aim of the device is to detect a potential seizure and deliver an IT-triggered stimulation to the vagus nerve in an automatic magnet mode.


(2) For the purpose of the E36 study, ictal tachycardia was defined as an increase in heart rate during a seizure, specifically exceeding 100 bpm and increasing by at least 55% or 35 bpm above baseline. In clinical practice, only a 20% increase in heart rate is needed to benefit from AMM.


(3) The SDA setting can detect seizures starting at a 20% increase in heart rate. The threshold for detection needs to be determined individually on the basis of previous seizures recorded at the monitoring unit.

 

 

 

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