John Libbey Eurotext

Brain connectivity changes during ictal aggression (a strangulation attempt) Volume 19, issue 3, September 2017


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Université Aix Marseille, Institut de neurosciences des systèmes and AP-HM, Hôpital de la Timone, Service de neurophysiologie clinique, Marseille, France
* Correspondence: Fabrice Bartolomei Service de neurophysiologie clinique, CHU Timone, 264, rue Saint-Pierre, 13005 Marseille, France

Ictal aggressive behaviour is a rare manifestation of focal seizures. We report an episode of ictal aggression occurring during an intracerebrally recorded seizure (using stereoelectroencephalography) in a patient with drug-resistant temporal lobe epilepsy. Aggression occurred during the last part of the seizure and was coincident with marked EEG slowing of the frontal regions and persistent ictal activity in the medial temporal lobe. A functional connectivity study (h2 estimation of interdependencies) showed a bilateral massive hypersynchronization between frontal and temporal regions. This case illustrates the occurrence of aggression during imbalance between the electrical activity in the temporal limbic cortex and prefrontal cortex, in agreement with the current neurobiological theories of aggression.