Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA
Correspondence: Gregory L. Holmes
Department of Neurological Sciences,
Larner College of Medicine,
University of Vermont,
Stafford Hall, 118C,
Burlington, VT 05405, USA
Benign Rolandic epilepsy (benign epilepsy with centrotemporal spikes; recently renamed self-limited epilepsy with centrotemporal spikes) is associated with widespread deficits in cognition and behavior, suggesting abnormalities in networks that extend beyond the centrotemporal region. To assess functional connectivity in children with benign Rolandic epilepsy, we assessed EEG spectral power and coherence during awake and sleep records in 27 children with centrotemporal spikes. Coherence represents the consistency of the phase difference between two EEG signals when compared over time and serves as a measure of synchronization between two EEG signals based mainly on phase consistency.