John Libbey Eurotext

European Journal of Dermatology


Ultrastructural and morphological analysis during progression of Bowen disease reveals a complex interplay between hyperkeratosis, cytokeratin expression, host immunity and amyloid deposition Volume 33, issue 3, May-June 2023


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1 Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan
2 Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
* Reprints: Hiroyuki Goto

Cytokeratins (or keratins) are intermediate filament proteins of the epithelia that play an important role in the mechanical stability of epithelial cells [1]. Keratin filaments are composed of type I (acidic) and type II (basic) molecules, and their components differ depending on the cell type and tissue [1]. According to recent studies, cytokeratins are involved not only in the structural stability of cells but also in intercellular signalling pathways including those associated with wound healing, [...]