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European Journal of Dermatology

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Selenium disulfide: a key ingredient to rebalance the scalp microbiome and sebum quality in the management of dandruff Volume 33, supplement 1, Mars 2023

Figure 1

Study 1: Evolution over time of mean scores for adherent dandruff.

Differences between SeS2 and the vehicle were significantly (*p<0.001) at all post-baseline (D0) visits for mean adherent dandruff scores.

Figure 2

Study 1: Scalp bacterial diversity using the Shannon Index for lesional and non-lesional zones.

A) Lesional zone

B) Non-lesional zone

Shannon indices measuring microbial diversity and richness were used to compare both lesional and non-lesional zones from both treatment and vehicle groups over time.

Bacterial diversity was not modified by SeS2 compared to the vehicle, either during the active phase or the follow-up period, at both lesional and non-lesional zones.

Figure 3

Study 1: bacterial OTU composition dissimilarity as measured using Bray-Curtis , with SeS2 and the vehicle

Bray-Curtis Indices were used to compare changes in the spread of bacterial OTUs at lesional zones in both treatment and vehicle groups over time.

A) SeS2 caused changes in the relative distribution of bacterial OTUs towards greater diversity, at D28 and D35. This variation returned to baseline levels after 56 days.

B) Vehicle-treated group showing no change over time in the relative OTU distribution

Figure 4

Study 1: SeS2 reduces numbers of Malassezia spp. and Staphylococcus spp.

Subjects having received SeS2 showed reduced numbers of Malassezia spp. and Staphylococcus spp. by about -2Δlog to -1Δlog respectively, at D28 and 35 at both lesional and non-lesional zones (p<0.001) when compared to D0 and the vehicle group.

By D56, the number of these 2 microorganisms had returned to near-D0 levels. Cutibacterium spp. numbers did not vary at D35 and between the SeS2 and the vehicle group for both lesional and non-lesional zones. Cutibacterium spp. numbers were significantly increased by ~+04Δlog with SeS2 treatment (p<0.001), but only at the lesional zone at D56.

Figure 5

Study 1: Ratio Malassezia spp. vs Cutibacterium spp.

A significant (p<0.001) difference at D28 and D35 compared to baseline were observed between SeS2 and the vehicle for the ratio of number of Malassezia spp. Cutibacterium spp.

Figure 6

Study 2: Changes over time of mean total dandruff severity scores compared to baseline

At all-time points, mean total dandruff scores were significantly (p<0.01) improved from baseline. During the follow-up phase a slow increase to baseline values was observed, with a maintenance of a significant (p<0.01) clinical benefit.

Figure 7

Study 2: Changes over time of the mean scores in the self-perception of the severity of scaling, itch and scalp greasiness

At all visits, the subjects significantly (p<0.05) self-perceived the decease of scores for the 3 signs as compared to baseline.