European Journal of Dermatology
MENUPrediction of surgical margin width using Mohs micrographie surgery for extramammary Paget’s disease based on clinicopathological parameters: classification tree analysis of 150 cases Volume 32, issue 1, January-February 2022
- Key words: classification tree analysis, extramammary Paget’s disease, Mohs micrographic surgery, surgical margin
- DOI : 10.1684/ejd.2022.4204
- Page(s) : 107-12
- Published in: 2022
Background
Extramammary Paget's disease (EMPD) frequently extends beyond clinical borders, causing a high recurrence rate. Mohs micrographic surgery (MMS) has been used for management of EMPD, but its efficiency is compromised by technical limitations inherent in MMS.
Objectives
To identify clinicopathologic parameters of predictive value regarding MMS final margin width (FMW) for EMPD, and provide some preliminary guidance in selecting initial surgical margin width for improved efficiency.
Materials & Methods
This was a retrospective study of 150 consecutive EMPD patients who underwent MMS between 2013 and 2019. Clinicopathological parameters and surgical data were collected to construct a classification tree of FMW.
Results
A six-node classification tree with a sensitivity of 86.25% and a specificity of 48.57% was generated. Lesion width, disease duration and inflammation score were used to select subgroups of patients in whom optimal initial margin width may be recommended.
Conclusion
Classification tree analysis may help identify important variables to consider when selecting MMS initial surgical margins for EMPD