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European Journal of Dermatology

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Necrotizing fasciitis with slow progression in a patient with rheumatoid arthritis receiving tocilizumab Volume 32, issue 2, March-April 2022

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Authors
1 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Department of Dermatology, Kagawa University Faculty of Medicine, Kagawa, Japan

Necrotizing fasciitis (NF) is a rapidly progressive, lifethreatening infection involving the skin, soft tissue and deep fascia [1]. The pathogenesis of NF with group A Streptococcus pyogenes (GAS) infection is thought to involve interleukin-6 (IL-6), tissue-damaging enzymes released by activated host neutrophils, and uncontrolled T-cell responses to superantigens [2]. Tocilizumab, an anti-IL-6 receptor monoclonal antibody, reduces the disease activity of rheumatoid arthritis (RA) by the blockade [...]