European Journal of Dermatology
MENUNecrotizing fasciitis with slow progression in a patient with rheumatoid arthritis receiving tocilizumab Volume 32, issue 2, March-April 2022
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1 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Department of Dermatology, Kagawa University Faculty of Medicine, Kagawa, Japan
- DOI : 10.1684/ejd.2022.4249
- Page(s) : 279-80
- Published in: 2022
Necrotizing fasciitis (NF) is a rapidly progressive, lifethreatening infection involving the skin, soft tissue and deep fascia [1]. The pathogenesis of NF with group A Streptococcus pyogenes (GAS) infection is thought to involve interleukin-6 (IL-6), tissue-damaging enzymes released by activated host neutrophils, and uncontrolled T-cell responses to superantigens [2]. Tocilizumab, an anti-IL-6 receptor monoclonal antibody, reduces the disease activity of rheumatoid arthritis (RA) by the blockade [...]