John Libbey Eurotext

European Journal of Dermatology

MENU

Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions Volume 32, issue 2, March-April 2022

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Authors
1 Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland
2 Department of Pathology, Kuopio University Hospital, 70210 Kuopio, Finland
3 Department of Pathology, University of Eastern Finland, 70210 Kuopio, Finland
4 Biobank of Eastern Finland, Kuopio University Hospital, 70210 Kuopio, Finland
Reprints: Ilkka T. Harvima

Background

Patients with cutaneous malignant melanoma (CMM) are at increased risk of non-melanoma skin cancers (NMSCs) and possibly precancerous lesions.

Objectives

To analyse the association between CMM and not only NMSCs but also precursor lesions, actinic keratosis (AK) and Bowen disease (BD).

Materials & Methods

The Finnish Cancer Registry data was used to calculate the age-standardized incidence ratio during 2000-2013 for basal (BCC) and squamous (SCC) cell carcinoma in patients with CMM. All tissue material collected from 70,420 subjects during 2000-2013 and reposited in the Biobank of Eastern Finland was used to calculate the age-standardized prevalence of BCC, SCC, BD and AK in CMM patients.

Results

In both genders, the age-standardized incidence ratio of BCC and SCC was increased in CMM patients. The age-standardized prevalence of NMSCs and precursor lesions was higher in patients with CMM than in those without CMM, and was higher in CMM patients with immunosuppression (IS) than in those without IS. The association of M-Snomed subtypes, lentigo maligna (LM), melanoma in situ (MIS) and malignant melanoma (MM) with AK and/or BD was stronger than with BCC. LM revealed the highest association with the combination of AKBD-SCC. Male subjects showed a higher age-standardized prevalence of CMM, MM and BCC than females, but the opposite was observed for AK.

Conclusion

Melanoma increases the risk of NMSCs, and IS may enhance this risk. Both malignant and in situ subtypes of melanoma associate with not only BCC and SCC, but also precancerous lesions.