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European Journal of Dermatology

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Linear immunoglobulin A bullous dermatosis complicating ulcerative colitis after a missed abortion Volume 32, issue 5, September-October 2022

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Authors
1 Kagawa University Hospital Post Graduate Clinical Education Center, Miki-cho, Kagawa, Japan
2 Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
3 Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
4 Departments of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Miki-cho, Kagawa, Japan
5 Department of Dermatology, Kagawa University Faculty of Medicine, Miki-cho, Kagawa, Japan

Linear immunoglobulin A disease, also known as linear IgA bullous dermatosis (LABD), is an autoimmune subepidermal blistering disease characterized by linear IgA deposits at the basement membrane zone (BMZ) based on direct immunofluorescence (DIF). IgA autoantibodies to the 120-kDa and 97-kDa shed ectodomains of type XVII collagen (COL17, BP180) are most frequently detected. Ulcerative colitis (UC) is the most common non-malignant disease associated with LABD [1]. LABD improves during pregnancy [...]