Central R&D Laboratory, Pias Corporation,1-3-1, Murotani, Nishi-ku, Kobe city, 651-2241, Japan
Acseine Corporation, 3-19-3, Toyosaki, Kita-ku, Osaka, 531-0072, Japan
Department of Dermatology, Wakayama Medical University, 811-1, Kimiidera, Wakayama city, 641-0012, Japan
Iderea Skin Clinic Daikanyama, 17-6, Daikanyama-cho, Shibuya-ku,Tokyo, 150-0034, Japan
Background: There are few studies on skin aging in patients with atopic dermatitis (AD). Objectives: To clarify the characteristics of facial skin aging in AD patients. Materials & Methods: Using facial images obtained by a digital imaging system (VISIA evolution), we compared the severity scores for 10 aging signs in 53 women in the AD group and 29 women in the healthy control group, all 35-49 years old. Results: The severity scores for fine lines on the forehead, periorbital wrinkles, nasolabial folds, and texture of the mouth contour were significantly higher in the AD group than in the controls. However, in order to exclude a direct effect of dermatitis at the time of measurement, cases with signs of AD at the evaluation site were excluded from the AD group (defined as the AD [non-lesion] group), revealing no statistical significance between the AD (non-lesion) group and the healthy control group for any of the 10 facial signs. Age subset analysis showed that for individuals in their late 40s, the AD (non-lesion) group exhibited significantly higher scores for crow’s feet wrinkle and nasolabial fold compared to the healthy control group. Furthermore, these two scores correlated with one other, suggesting that they may be induced by the same factors. Conclusion: The results of this study show that skin aging associated with AD is prominent in areas prone to transient wrinkling by frequent blinking and speaking or facial expressions. Understanding of the need for appropriate AD treatment from a cosmetic perspective may increase patient adherence.