John Libbey Eurotext

Bulletin du Cancer


Oncogenes and thyroid tumors Volume 92, issue 1, Janvier 2005


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Institut Gustave-Roussy, 94805 Villejuif Cedex

Papillary thyroid carcinomas are characterized in 70 % of cases by the presence of either a RET/PTC rearrangement, or an activating point mutation of RAS or BRAF genes that induce a constitutive activation of the MAP kinase pathway. Follicular carcinomas are characterized by the presence of a RAS mutation or of a PAX8-PPARγ rearrangement. Inactivating mutations of the p53 gene are found only in anaplastic thyroid carcinomas.