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Bulletin du Cancer

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Epidermal growth factor receptor (EGF) in head-and-neck cancers Volume 94, supplement 6, Suppl. FMC numéro 7 : Thérapeutiques ciblées : malades sélectionnés

Authors
Institut Gustave Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif.

EGFR is frequently overexpressed and is associated with a poor prognosis in head and neck carcinoma (HNC). Among the biological and cellular effects resulting from EGFR targeting, there are the possibilities to restore apoptotic capacities and to reduce DNA-repair activity, to inhibit angiogenesis and tumor cell migration. This suggests the potential interest of the combination between anti-EGFR drugs and cytotoxic agents, especially ionizing radiation with promising results obtained at the clinical level in locally advanced HNC.