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Cyclooxygenase 2 inhibitors and cancer chemoprevention Volume 91, special issue 2, Numéro spécial, Mai 2004

Authors
 Département de médecine, Institut Gustave‐Roussy, 39 rue Camille‐Desmoulins, 94805 Villejuif  Laboratoire de radiobiologie et oncologie, CEA, DSV\DRR, 10, route du Panorama, 92265 Fontenay‐aux‐Roses E‐mail : soria@igr.fr

Chemoprevention is the use of natural or synthetic compounds in order to reverse, suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase‐2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and anticancer effects. Indeed, Cox2 overexpression contributes to the carcinogenic by at least 5 different mechanisms including transformation of procarcinogens on carcinogens, pro‐inflammatory and immunomodulatory effect, resistance to apoptosis, angiogenesis and invasion progression… This review will focus on the rationale and the ongoing research areas related to chemopreventive approaches targeting Cox2.