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Usefulness of a pharmacokinetic approach for clinical antineoplastic chemotherapy evaluation Volume 86, issue 4, Avril 1999

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Service de pharmacologie clinique, Centre René-Huguenin, 35, rue Dailly, 92210 Saint-Cloud.

Pharmacokinetics, which is the study of the drug becoming in the body, is an important approach of new drug evaluation. Anticancer drugs have mostly a very narrow therapeutic index which leads to a delicate clinical use. Pharmacokinetics permits the prediction of the occurrence of iatrogenic toxicities taking into account the interpatient variability of the pharmacokinetic parameters.