John Libbey Eurotext

Bulletin du Cancer


Current concepts on apoptotic signalling pathways: new targets for anticancer strategies Volume 90, issue 1, Janvier 2003


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Inserm U496, Centre G. Hayem, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris

Apoptosis is an essential physiological process that plays a critical role in development and cellular homeoastasis. This process is tightly regulated through multiple independent signalling pathways. Defects in apoptosis may contribute both to tumorigenesis and drug resistance. Understanding the molecular events that contribute to apoptosis enable a more rational approach to anticancer strategy development. These strategies will allow not only the development of new molecules targeting recently elucidated apoptotic signalling pathways, but also a better use of already kown drugs through new associations in so far as these target distinct signalling pathways.