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NSE & S100B protein blood level assessment during a long-distance trail race Volume 77, issue 5, Septembre-Octobre 2019

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Authors
1 Intensive care unit, Anaesthesiology, SAMU, Necker-Enfants malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France
2 Departments of anaesthesia, Clinical epidemiology and biostatistics, Michael De Groote school of medicine, Faculty of health sciences, McMaster University, Hamilton, Ontario, Canada
3 IRMES - Institute for research in medicine and epidemiology of sport, Paris, France
4 UMR-S 1075-COMETE Mobilités : vieillissement, pathologie, santé, Pôle des formations et de recherche en santé (PFRS), Université de Caen Normandie, Inserm, Caen, France
5 Unité de chronobiologie, Fondation Rothschild, Paris, France
6 Assistance Publique-Hôpitaux de Paris, Psychiatry department, Hôpitaux universitaires Henri Mondor – Albert Chenevier, Université Paris-Est, Créteil, France
7 Sorbonne Universités, UPMC Université Paris 06, CNRS, Inserm, Institut du cerveau et de la moelle épinière (ICM), Paris, France
8 Department of mental health and psychiatry, Global health institute, University of Geneva, Geneva, Switzerland
9 Department of clinical chemistry, Necker-Enfants malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France
10 Université de Paris, Faculté de pharmacie, Paris, France
* Correspondence

The acute and chronic consequences of long-distance running on brain function have received little attention. The impact of such a hard-physical burden associated with sleep privation during such events such has never been explored in terms of neuropsychological function and brain damage. Methods. Blood samples were collected from 4 athletes before, during and at the end of one of two races: Grand Raid de la Réunion 2017 (GRR: 165 km, elevation gain: 9529 m, 2 runners) and Trail de la Bourbon 2017 (TB: 111 km, elevation gain: 6433 m, 2 runners). Serum S100B and NSE levels were measured for each runner before, during and after the race. Results. Serum S100B levels (normal range: < 0.15 μg/L) increased early during the race and remained high up to the end of the race in all 4 runners (range: 0.17-0.59 μg/L). NSE level (normal range: < 15 μg/L) increased in 3 of the 4 runners (range: 16.8-39.2 μg/L). Conclusions. This preliminary study shows the potential interest of S100B and NSE serum assessment during long-distance races. Further studies are needed to confirm these results and to investigate the origins and significance of this increase in brain injury markers.

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