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POCT management of neonatal bilirubinemia – guidelines for an optimization of kernicterus monitoring Volume 80, issue 6, November-December 2022

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Tables

Authors
1 Département de biochimie, hormonologie et suivi thérapeutique,
2 Service d’hémobiologie fœtale et périnatale, Unité fonctionnelle d’expertise en immuno-hémobiologie périnatale, Centre national de référence en hémobiologie périnatale (CNRHP), DMU de biologie et génomique médicales (BioGeM), GH AP-HP, Sorbonne Université, Site Saint-Antoine, Paris
Correspondance : A. Mailloux

In pediatrics, accurate measurement of total serum bilirubin (TSB) is of major importance for reliable diagnosis and appropriate management of neonatal jaundice. However, several studies evidenced poor comparability of results obtained with the different available methods either in central lab or in POCT, on serum, capillary blood or transcutaneous. This situation is partly due to the lack of Reference Materials, especially for high bilirubin concentrations but also on poor communication between central lab and neonatology unit. To progress on these issues, we have compiled some data from CNRHP to propose guidelines for choice, use and management of POCT devices and to help clinical laboratories to achieve a better answer to clinical needs with specific local constraints. The results from several CNRHP studies are presented: traceability to International System of Units, inter-laboratories comparability, POCT vs central labs comparisons with POCT CO-oximeter or photometer, integration of transcutaneous bilirubinometer. We propose, based on an analysis of devices advantages and issues, guidelines to help labs either to improve neonates monitoring in their local context; we distinguished the choices inside laboratory for a better harmonization of results compared to published thresholds and outside lab contexts, to organize a coordinated chain with POCT devices, with capillary and/or transcutaneous approaches.