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Annales de Biologie Clinique

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Rare sideroblastic anemias: about 2 cases, review of the literature and reminder of the main etiologies Volume 79, issue 1, Janvier-Février 2021

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Authors
1 Service de médecine interne, Centre hospitalier de Royan, Vaux-sur-Mer
2 Service de pédiatrie, Centre hospitalier de Saintonge, Saintes
3 GCS de Saintonge, Centre hospitaliers de Saint-Jean-d’Angély, Saintes et Royan, Saint-Jean-d’Angély
* Correspondance

Sideroblastic anemias in adults are often quickly labeled as myelodysplasias. We report two unfrequent observations of secondary acquired forms. The first one is a 15-year-old girl presented with severe cytopenias. The myelogram revealed the presence of vacuolated myeloid and erythroblastic precursors, with ring sideroblasts. Copper deficiency has been demonstrated in front of the association with collapsed cupremia and ceruleoplasminemia, with normal cupruria. The second case is a 70-year-old man, treated for 1 month with several lines of antibiotics for a skin infection, referred for cytopenias. The myelogram found vacuolated erythroblastic precursors and ring sideroblasts. Linezolid's responsibility has been proposed, with a favorable development after treatment has been stopped. These two observations, which describe unfrequent sideroblastic anemias, point out that this discovery should not lead to the diagnosis of myelodysplasia before having considered the many other etiologies.