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Inhibition of NO prtoduction in macrophages by interleukin-13 is counteracted by Herpes simplex virus infection throug tumor necrosis factor-a-induced activation of NK-KB. Volume 11, numéro 2, June 2000

Auteurs
Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark.
  • Page(s) : 275-82
  • Année de parution : 2000

INTRODUCTION Among the mechanisms involved in natural resistance against infections, production of nitric oxide (NO) by activated macrophages has recently been found to play a central role, reducing growth and replication of parasites, bacteria and viruses [1-5]. Since NO, in a manner not discriminating friend from foe, potently inhibits protein, lipid and DNA function [6-8], it is essential that the generation of NO is not left uncontrolled. [...]