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Magnesium Research

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The influence of α‐zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny Volume 16, numéro 2, June 2003

Auteurs
Department of General Chemistry Medical University of Lublin, Poland Department of Hygiene Medical University of Lublin, Poland

The purpose of the research work was to study the influence of α‐zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received α‐zearalenol at the doses of: 0.05, 0.5 or 1 mg·kg ‐‐1 b.w. After delivery, brain, liver and kidneys of female rats and their progeny were removed and magnesium concentration was measured in cellular subfractions of these tissues. α‐zearalenol reduced Mg‐level in all the cellular subfractions of female rat tissues. In progeny tissues, α‐zearalenol decreased magnesium concentration in nuclear subfraction only. In mitochondrial and cytosol subfractions it increased Mg‐concentration. The changes in magnesium concentration were depended on α‐zearalenol doses and tissue nature. The magnesium concentration decrease was higher in female rats than in progeny tissues.