John Libbey Eurotext

Magnesium Research

The influence of oral steroidal contraceptives on magnesium concentration in breast milk Volume 26, numéro 4, October-November-December 2013

  • Auteur(s) : Denise Urzica, Cristina Gales, Carmen Zamfir, Mihai Nechifor , Cuza-Voda Obstetrics-Gynaecology University Hospital, Iasi, Romania, Department of Histology “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Department of Pharmacology “Gr. T. Popa” University of Medicine and Pharmacy, Universitatii16, Iasi 70015, Romania
  • Mots-clés : oral steroidal contraceptives, magnesium, blood plasma, breast milk, mini-pill
  • Page(s) : 188-91
  • DOI : 10.1684/mrh.2014.0353
  • Année de parution : 2013

This study determined the total magnesium concentration in the breast milk of mothers that were using oral, steroidal contraceptives during lactation. The study involved two groups of breast-feeding mothers that were receiving oral contraception, and a control group of 15 breast-feeding mothers that did not receive oral contraception. The first group received a daily combination pill (levonorgestrel 0.15 mg + ethinylestradiol 0.03 mg); the second group received a daily mini-pill (progestin-only pill, containing norethindrone 0.35 mg). The total magnesium concentrations of plasma and breast milk were determined before the start of contraception and after 30 days of contraception. The results showed that after 30 days of contraception, the contraceptive drugs had not significantly modified the total breast milk magnesium concentration (1.16 ± 0.11 mmol/L before treatment versus 1.01 ± 0.12 mmol/L, in first group; 0.97 ± 0.16 mmol/L before contraception versus 1.08 ± 0.11 mmol/L, in the second group). There were no significant changes in the total magnesium concentration in the breast milk of the control group after the 30 days. In addition, the oral, steroidal contraceptives (pill and mini-pill) did not affect the total magnesium concentration in the plasma of lactating mothers.