John Libbey Eurotext

Magnesium Research

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Mg 2+: a potent inhibitor of collagen‐induced in vitro mineralization Volume 17, numéro 2, June 2004

Auteurs
Department of Biochemistry, Panjab University, Chandigarh‐160014 Jaypee University of Information Technology, Waknaghat, Solan (H.P.)

At physiological concentrations, Mg 2+ has been found to be a potent inhibitor of collagen‐induced in vitro mineralization. Mg 2+ inhibits mineralization by competing with Ca 2+ for specific phosphate independent Ca 2+ binding sites of the catalytic matrix. Matrix bound Mg 2+ subsequently reacts with HPO 4 2‐‐ to form MgHPO 4 complex which can not be further converted to the matrix bound mineral phase. The matrix, as well as the mineral phase associated with the matrix, influence the rate of mineralization.