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Blood pressure, magnesium and other mineral balance in two rat models of salt-sensitive, induced hypertension: effects of a non-peptide angiotensin II receptor type 1 antagonist Volume 27, numéro 3, Juillet-Août-Septembre

Illustrations


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Tableaux

Auteurs
1 Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Biofísica y Bioquímica, Laboratorio de Fisiología Molecular, Altos de Pipe, Estado Miranda, Venezuela
2 IVIC, Centro de Química, Laboratorio de Química Analítica, Altos de Pipe, Estado Miranda, Venezuela
* Correspondence: Rondón Lusliany. Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Biofísica y Bioquímica, Laboratorio de Fisiología Molecular, Altos de Pipe, Estado Miranda, Venezuela.

The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increased arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility, and vascular tone. To evaluate the relationship between high BP induced by a high sodium (Na) diet and Mg, and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II infused and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SS rats fed a high Na diet had a slow pressor response, accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K balances. Mg metabolism maybe considered a possible defect in this strain of rat that may contribute to hypertension.