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 Version imprimable |
Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans |
European Journal of Dermatology. Volume 22, Numéro 1, 58-67, January-February 2012, Investigative report
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 Free Article
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Auteur(s) : Hui Zhao, Joel Deneau, Ginny O.L. Che, Shang Li, Frederic Vagnini, Parastoo Azadi, Roberto Sonon, Ravi Ramjit, Simon M.Y. Lee, Krzysztof Bojanowski |
Résumé : This report characterizes an aqueous isolate (SBD.4) of one of the most broadly used Chinese medicinal herbs,
Angelica sinensis, from the perspective of its application in skin and wound care. SBD.4 has been chemically defined and was found to increase the strength of healed wounds in retired breeder (older) rats. Furthermore, the mechanism of action of this
Angelica sinensis isolate was tested in the zebrafish angiogenesis model, and in human skin substitutes by DNA microarray, revealing a bioactivity profile consistent with skin repair and regeneration. When combined with several types of wound dressings, SBD.4 increased type I collagen production in human dermal fibroblasts, and when formulated in nanosilver hydrocolloid dressing, it was found effective in chronic ulcer management in humans, demonstrating that botanical high-tech wound dressings can be successfully developed to improve the treatment of chronic lesions in humans. |
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