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 Version imprimable |
Effects of Hydroxydecine
® (10-hydroxy-2-decenoic acid) on skin barrier structure and function
in vitro and clinical efficacy in the treatment of UV-induced xerosis |
European Journal of Dermatology. Volume 21, Numéro 6, 906-15, November-December 2011, Investigative report
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 Full Text
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Auteur(s) : Hélène Duplan, Emmanuel Questel, Hélène Hernandez-Pigeon, Marie Florence Galliano, Antony Caruana, Isabelle Ceruti, Marco Ambonati, Carine Mejean, Odile Damour, Nathalie Castex-Rizzi, Sandrine Bessou-Touya, Anne-Marie Schmitt |
Résumé : 10-Hydroxy-2-decenoic acid, a natural fatty acid only found in royal jelly, may be of value in correcting skin barrier dysfunction. We evaluated the activity of Hydroxydecine
®, its synthetic counterpart,
in vitro on the regulation of epidermal differentiation markers,
ex vivo on the inflammatory response and restoration of skin barrier function, and
in vivo on UV-induced xerosis in healthy human volunteers. In cultured normal human keratinocytes, Hydroxydecine
® induced involucrin, transglutaminase-1 and filaggrin protein production. In topically Hydroxydecine
®-treated skin equivalents, immunohistochemical analysis revealed an increase in involucrin, transglutaminase-1 and filaggrin staining. In a model of thymic stromal lymphopoietin (TSLP)-induced inflamed epidermis, a Hydroxydecine
®-containing emulsion inhibited TSLP release. In a model of inflammation and barrier impairment involving human skin explants maintained alive, Hydroxydecine
® balm restored stratum corneum cohesion and significantly increased filaggrin expression, as shown by immunohistochemistry. It also decreased pro-inflammatory cytokine secretion (IL-4, IL-5 and IL-13). In healthy volunteers with UV-induced xerosis, the hydration index increased by +28.8% (p<\;0.01) and +60.4% (p<\;0.001) after 7 and 21 days of treatment with Hydroxydecine
® cream, respectively. Hydroxydecine
® thus proved its efficacy in activating keratinocyte differentiation processes
in vitro, restoring skin barrier function and reducing inflammation
ex vivo, and hydrating dry skin
in vivo. |
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