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 Version imprimable |
Effect of narrow band ultraviolet B on survivin in psoriatic skin lesions |
European Journal of Dermatology. Volume 21, Numéro 6, 866-9, November-December 2011, Investigative report
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Auteur(s) : Noha Abdel Rehim Nagui, Rania Mounir Abdel Hay, Laila Ahmed Rashed |
Résumé :
Background: Suppression of apoptosis is responsible for epidermal thickness in psoriasis. Survivin is an anti-apoptotic protein that can be modulated by ultraviolet B (UVB).
Aim: Our aim was to investigate the role of survivin in psoriasis and to evaluate the effect of narrow band (NB)-UVB on the survivin levels in psoriatic lesions. Methods: This study included 20 psoriatic patients and 20 healthy controls. Patients were treated with 24 sessions of NB-UVB. Skin biopsies were taken from the affected skin of each patient before and after treatment, and from the controls, to examine survivin levels by ELISA.
Results: Survivin was significantly upregulated in psoriasis compared to controls (p<\;0.001). We found significant positive correlations between survivin levels before therapy and the extent of body involvement (r\=0.675, p\=0.002), as well as the PASI score (r\=0.67, p\=0.001). A significant decrease in survivin levels was observed post treatment compared to baseline levels (p<\;0.001).
Conclusion: We found increased survivin levels in psoriasis and a significant reduction following NB-UVB induced clinical improvement of psoriasis. |
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