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 Version imprimable |
Development and
in vitro assay of oxidative stress modifying formulations for wound healing promotion |
European Journal of Dermatology. Volume 21, Numéro 2, 52-62, May 2011, Review article
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 Free Article
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Auteur(s) : Nicolas ATRUX-TALLAU, Sylvie CALLEJON, Camille MIGDAL, Karine PADOIS, Valérie BERTHOLLE, Alain DENIS, Marlène CHAVAGNAC-BONNEVILLE, Marek HAFTEK, Françoise FALSON, Fabrice PIROT |
Résumé : Often presented as metabolism byproducts, reactive oxygen species are linked to detrimental effects such as chronic wound, mutagenesis, cancer and skin ageing. However, recent
in vitro and
in vivo observations suggest that ROS, and mainly hydrogen peroxide, interfere with cell signaling acting like second messenger and inducing adaptive responses. This is particularly observed in skin wound healing where cells are exposed to H
2O
2 following injury. In this study, we developed and characterized an innovative formulation producing H
2O
2 at low concentrations, in order to mimic physiological inflammation phase. Then, this pro-oxidative formulation (CAM-GOx) was assayed
in vitro on keratinocytes cell culture, compared to the blank formulation (CAM) and the anti-oxidative formulation (CAM-CAT) to assess whether oxidative stress was implied or not in cellular responses. |
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