Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline

Illustrations

Figure 1 Flow chart of subject disposition.

Figure 2 Maintenance success rates (ITT, worst case).

Figure 3 Reduction in lesion counts from baseline of previous combination study at baseline and week 12 of current maintenance study.

Figure 4 Effect of 12 weeks of maintenance therapy with adapalene gel 0.1% following 12 weeks of combination therapy with adapalene gel 0.1% plus lymecycline on moderate to moderately severe facial acne lesions. Photos show subject treated with lymecycline and adapalene gel 0.1% at baseline of the combination study (A), after 12 weeks of combination treatment with adapalene gel 0.1% plus lymecycline (B); this time point is also the baseline for the maintenance study), and following 12 weeks of maintenance treatment with adapalene gel 0.1% (C).

Figure 5 Local tolerability. Effects of adapalene vs. gel vehicle on mean scores for skin tolerance variables: (A) erythema, (B) scaling, (C) dryness, and (D) stinging/burning. Skin tolerability variables were assessed according to the following scoring scale: none = 0, mild = 1, moderate = 2, and severe = 3. Mean scores at each post baseline visit and worst score (worst observation recorded for a subject during the post baseline period) are included in the figure.