Auteur(s) : Mariko SEISHIMA, Tomoko IZUMI, Yasuo KITAJIMA, Department of Dermatology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki 503-8502, Japan..
Illustrations
Figure 1. Clinical features of bulla formation on the right lower leg.
Figure 2. Histological findings of a subepidermal bulla (haematoxylin
and eosin staining). Bar indicates 100 µm.
Figure 3. The results of immunoblot analysis using human epidermal extracts
as a substrate. Monoclonal antibodies to 230 kDa BPAG1 (lane 1) and 180
kDa BPAG2 (lane 3) react with only their specific bands. The patient's
serum (lane 2) and typical BP serum (lane 4) react with 230 kDa and 180
kDa polypeptides, respectively. Control normal serum showed negative (lane
5).
Figure 4. Immunofluorescence studies. Indirect immunofluorescence (IDIF)
findings for normal skin show a linear deposition of IgG at basement membrane
zone (BMZ) (A). A linear deposition may be observed on the epidermal
side of skin split by 1 M NaCl (B). In direct immunofluorescence
study, IgG deposition was positive at the BMZ in perilesional skin (C).
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