John Libbey Eurotext



French consensus on myelodysplastic syndromes (MDS), and chronic myelomonocytic leukemia: diagnosis, classification and treatment Volume 21, numéro 1, Janvier-Février 2015


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MDS are clonal pluripotent, stem cell disorders characterized by ineffective hematopoiesis resulting in blood cytopenias contrasting with a typically cellular marrow. MDS evolve frequently to acute myeloid leukemia (AML), and are the most frequent preleukemic states in adults.MDS predominate in the elderly, with a median age at diagnosis of about 70 years. Their incidence is 4 to 5 per 100,000 persons per year. Their etiology is generally unknown. In 15 to 20% of cases, however, MDS are secondary [...]