John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

The link between structural connectivity and neurocognition illustrated by focal epilepsy Volume 20, numéro 2, April 2018

Illustrations

  • Figure 1
  • Figure 2
Auteurs
1 LPNC UMR 5105, CNRS, Univ. Grenoble Alpes, Grenoble
2 GIN-IMN, UMR 5293, CEA/CNRS, Université de Bordeaux, Bordeaux
3 GIN, U836 UGA/INSERM “Synchronisation et modulation des réseaux neuronaux dans l’épilepsie”, Grenoble University Hospital, Grenoble, France
* Correspondence: Monica Baciu Laboratoire de psychologie et neurocognition, UMR CNRS 5105, Université Grenoble Alpes, BP 47 38040 Grenoble, Cedex 09 France
  • Mots-clés : connectivity, white matter, hodology, focal epilepsy, plasticity, cognition
  • DOI : 10.1684/epd.2018.0958
  • Page(s) : 88-98
  • Année de parution : 2018

Increasing attention is being paid to the assessment of white matter properties and its structural connectivity, both in healthy subjects and patients with cerebral lesions. Within this framework, new neurocognitive models based on hodological properties have been developed under a connectomic perspective in order to explain substrates and cognitive mechanisms related to cerebral functions such as language and memory. With regards to focal and drug-resistant epilepsy conceived as a network disorder, new insights in terms of structural connectivity have led to significant advances in epilepsy research, concerning fundamental research (neurocognitive mechanisms of plasticity) and clinical application (optimization of decision making for curative surgery). We believe that such findings in the literature, focused on the role of white matter in cerebral functioning in relation to neurocognition, may be helpful for both researchers and clinicians working in the field of epilepsy.