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The clinical pharmacology of traditional antiepileptic drugs Volume 16, numéro 4, December 2014

Figure 1

Inter-relationships between phenobarbitone, its congeners and their main metabolites.

The names of pharmacologically inactive molecules are shown in italics. The pattern of parahydroxylation of methylphenobarbitone is stereospecific, and may vary in extent between certain Asian and other populations.

Figure 2

Phenytoin and its main (pharmacologically inactive) metabolite.

Figure 3

Ethosuximide and its metabolic pathway.

Pharmacologically inactive molecules are shown in italics.

Figure 4

Inter-relationships between carbamazepine, oxcarbazepine and their main metabolites.

Pharmacologically inactive molecules are shown in italics.

Figure 5

Major valproic acid metabolic pathways.

Pharmacologically inactive molecules are shown in italics.

Figure 6

Structural formulae of the benzodiazepines discussed.