Epileptic Disorders
MENUSurgical control of limbic encephalitis associated with LGI1 antibodies Volume 14, numéro 3, September 2012
Illustrations
- Mots-clés : autoimmune epilepsy, hyperhidrosis, pilomotor, limbic encephalitis, LGI1 antibodies, voltage-gated potassium channel (VGKC), epilepsy surgery
- DOI : 10.1684/epd.2012.0515
- Page(s) : 345-8
- Année de parution : 2012
Limbic encephalitis with LGI1 antibodies may cause drug-resistant temporal lobe epilepsy. We report a case of a young man with progressive drug-resistant focal epilepsy, hyperhidrosis, and memory impairment associated with a left mesial temporal lesion. Epilepsy surgery was performed with the provisional diagnosis of cortical dysplasia or tumour. A neuropathological study following amygdalohippocampectomy revealed limbic encephalitis and LGI1 antibodies were identified in the serum. Two and a half years after surgery, the patient remains seizure-free without medication, with normal memory and without hyperhidrosis. Although immunosuppression is the first-line therapy for autoimmune limbic encephalitis, this case suggests that, in selected cases, a lasting response can be achieved with surgery.