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Epileptic Disorders

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Practical clues for diagnosing WWOX encephalopathy Volume 19, numéro 3, September 2017

Figure 1

Investigations at age 5 weeks. (A) EEG during sleep at the age of 4 weeks showing focal discharges on left centro-median derivations, associated with asymmetry of activity, slower on the left hemisphere. (B) Asymmetric fragmented hypsarrhythmia, greater on left than right derivations. Axial T1 (C), coronal T2 (D), and sagittal T2 (E) MR images at the age of 5 weeks, showing completely formed, but thin, corpus callosum and normal myelination for age, without other gross abnormalities.

Figure 2

Investigations at age 2.6 years. (A) EEG during wakefulness at the age of 2 years showing multifocal, bilateral, asynchronous epileptiform abnormalities on slower background (not as propagation). (B) Sleep hypsarrhythmia. Coronal T1 (C), axial T2 (D), and sagittal T1 (E) MR images at 2.6 years, showing significant supratentorial atrophy, delayed myelination, an extremely thin corpus callosum, and flattening of the brainstem.