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Genetic literacy series: clinical application of pharmacogenetics for adverse reactions to antiepileptic drugs. An ILAE Commission Review Volume 21, numéro 4, August 2019

TEST YOURSELF

(1) A 15-year-old patient is diagnosed with focal epilepsy. Both his parents are Han Chinese. You are considering treating him with an antiepileptic drug. Which of your antiepileptic drug choices would prompt you to do screening for HLA-B*1502 before commencing drug treatment?

A. levetiracetam

B. valproic acid

C. topiramate

D. carbamazepine

(2) You are planning to start antiepileptic drug treatment for a 30-year-old female with focal epilepsy. Her HLA-B*1502 test comes back as positive for the HLA-B*1502 allele. Which of the following antiepileptic drugs can be used safely, given the positive test?

A. carbamazepine

B. lamotrigine

C. levetiracetam

D. phenytoin

 

 

 

 

 

 

 

 

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Answers

(1) D.

 

(2) C.

 

 

 

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