John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Auditory seizures in autoimmune epilepsy: a case with anti-thyroid antibodies Volume 19, numéro 1, March 2017


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1 Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara
2 CRRF Mons. L. Novarese, Neurorehabilitation Unit, Moncrivello, VC
3 “C. Munari” Epilepsy Surgery Centre, Niguarda Hospital, Milan
* Correspondence: Gionata Strigaro Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
  • Mots-clés : Hashimoto's encephalopathy, autoimmune encephalopathy, status epilepticus, anti-thyroid antibodies
  • DOI : 10.1684/epd.2017.0904
  • Page(s) : 99-103
  • Année de parution : 2017

In its classic presentation, Hashimoto's encephalopathy is an acute-subacute complex neuropsychiatric syndrome with cognitive impairment, hallucinations, myoclonus, tremor or ataxia, associated with elevated anti-thyroid antibodies. Corticoids and immunotherapy are dramatically effective. However, in some cases, not all the associated features are presented and this delays diagnosis and appropriate treatment. We describe a man with abrupt onset of recurrent auditory seizures resulting in refractory non-convulsive status epilepticus. The patient was diagnosed with an autoimmune encephalopathy with elevated serum and CSF anti-thyroid antibodies. None of the antiepileptic drugs were successful, however, following immune-modulating therapy, the refractory non-convulsive status epilepticus dramatically improved, as did the patient overall. We suggest that Hashimoto's encephalopathy should be suspected in otherwise healthy patients with unexplained new-onset focal recurrent auditory seizures which do not respond to antiepileptic drugs. The presence of anti-thyroid antibodies in the CSF supports this diagnosis.