European Journal of Dermatology


Up-regulated perforin expression of CD8+ blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis Volume 10, numéro 5, July - August 2000

Department of Dermatology and Venereology, Universitätsklinik für Dermatologie und Venerologie, Otto-von-Guericke-University, Leipziger Str. 44, D-39120 Magdeburg, Germany.
  • Page(s) : 365-9
  • Année de parution : 2000

Cytotoxic T cells (CTL) are known to express the CD8 epitope and to recognize their targets through the T cell receptor in an MHC class I-restricted manner. In such a way specific lysis of target cells by CTLs is effected over secretory and non-secretory pathways [1, 2]. In the non-secretory cytolytic mechanism the linkage of the CTL over Fas ligands and Fas receptors to the target cell leads to its programmed death, i.e. apoptosis. On [...]