JLE

European Journal of Dermatology

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The safety of calcitriol 3 mg/g ointment. Evaluation of cutaneous contact sensitization, cumulative irritancy, photoallergic contact sensitization and phototoxicity Volume 11, numéro 3, May - June 2001

Auteurs
Galderma R&D, 635, route des Lucioles, BP 87, 06902 Sophia Antipolis Cedex, France.
  • Page(s) : 219-24
  • Année de parution : 2001

It is well established that the skin plays an important role in vitamin D metabolism, and that 1alpha, 25-dihydroxyvitamin D3, (1,25-(OH),D3 or calcitriol) the endogenously produced, hormonally active form of vitamin D3, is essential for the maintenance of calcium homeostasis. In addition, studies have shown that epidermal keratinocytes and dermal fibroblasts, in addition to other body tissues and various tumor cells, have a specific receptor for [...]