John Libbey Eurotext

European Journal of Dermatology

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Retinoid treatment of skin diseasesRetinoids in dermatology Volume 25, numéro 5, September-October 2015

Illustrations

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Tableaux

Auteurs
1 Department of Dermatology, SLK Hospital Heilbronn, Am Gesundbrunnen 20 -26, 74078 Heilbronn, Germany
2 Department of Dermatology and Allergology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
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  • Mots-clés : dermatopharmacology, retinoid therapy, retinoids, vitamin A derivatives
  • DOI : 10.1684/ejd.2015.2544
  • Page(s) : 384-91
  • Année de parution : 2015

Vitamin A (all-trans retinol) and its naturally occurring and synthetic derivatives, collectively referred to as retinoids, exert a wide variety of profound effects during embryogenesis, reproduction, regulation of inflammation, cell growth and cell differentiation. Their decisive role as critical gene regulators is primarily mediated by their interaction with the nuclear retinoic acid receptors (RAR) and retinoid-X-receptors (RXR) [1]. Isomers of retinoic acid are thought to be the major biologically [...]