John Libbey Eurotext

European Journal of Dermatology


PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis Volume 28, numéro 4, July-August 2018


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1 Division of Dermatology,
2 Department of Hematology, Endocrinology, and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Propylthiouracil (PTU) is a widely used anti-thyroid agent. PTU has been reported to cause anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis [1]. Cutaneous manifestations of PTU-induced ANCA-associated vasculitis (AAV) are similar to those of idiopathic AAV [2], such as microscopic polyangiitis. All reported patients have high titres of MPO-ANCA [3], however, MPO-ANCA does not necessarily correlate with disease activity in PTU-induced AAV [4-6]. Here, we report a case of PTU-induced [...]